Table 1.

Actions of piezo1 in other human diseases.

Disease types	Action	References
Anemia	Changes cell osmotic pressure	[162–165]
Hypertension	Regulates arteriole smooth muscle	[168, 169]
Atherosclerosis	Promotes atherosclerosis	[174–176]
Congenital lymphedema	Absence of piezo1 leads to lymph dysplasia	[178–180]
Pancreatitis	Induces Ca2+ expression	[183–185]
Colon cancer	Promotes expansion and metastasis	[188]
Gastric cancer	Promotes expansion and metastasis	[173, 189]
Breast cancer	Enhanced proliferation	[187]
Synovial sarcomas	Increased proliferation	[186]
Osteosarcoma	Inhibits apoptosis and promotes invasion and proliferation	[196, 197]
Bladder carcinoma	Promotes expansion and metastasis	[192]
Lung cancer	Promotes migration and tumor growth	[193]
Gliomas	Increased proliferation	[194, 195]