Figure 10.

Effect of Biobran (50, 100, and 200 mg/kg) on histopathological changes in the cerebral cortex of ICV-STZ injected mice, n = 3. Control: showing normal histological structure of the cerebral cortex of normal mice; ICV-STZ: showing diffuse gliosis in the cerebral cortex admixed with numerous degenerated neurons in the injected mice; Biobran 50 mg/kg: showing moderate number of degenerated neurons; Biobran 100 mg/kg: showing few injured neurons; Biobran 200 mg/kg: showing apparently normal cerebral cortex structure.