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Mechanisms of anthracycline-induced cardiotoxicity and the role of oxidative stress. DOX: doxorubicin; GSH-Px: glutathione peroxidase; MPO: myeloperoxidase; PGC1 α/β: peroxisome proliferator-activated receptor-γ coactivator 1-α and 1-β; Rac1: a subunit of NADPH oxidase; ROS: reactive oxygen species; SOD: superoxide dismutase.
