Table 5.

Differentially expressed innate and adaptive immune genes from chicken bursa in response to feed treatments compared to control.^1,2

Gene symbol	Fold change
	Bacitracin	CP1	CP2	COH150	COH300
C5AR1	−1.17∗	−1.31∗	−1.67∗	−1.39∗	−2.27∗
CASP1	−1.22∗	−1.16∗	−1.12∗	−1.56∗	−1.35∗
CCR8	−1.20∗	−1.15∗	−1.48∗	−2.09∗	−1.39∗
CD4	−1.15∗	−1.07∗	−1.06∗	−2.58∗	−1.07∗
CD14	−1.59∗	−1.79∗	−2.40∗	−1.09∗	−1.65∗
CD40LG	−1.30∗	−1.04∗	−1.26∗	−2.16∗	−1.34∗
CD8A	−1.78∗	−1.24∗	−1.87∗	−2.98∗	−1.86∗
CSF2	−1.02∗	−1.06∗	−9.81∗	−1.13∗	−1.24∗
IFIH1	−1.45∗	−1.02∗	−1.19∗	−2.22∗	−1.08∗
IFNG	−1.13∗	−1.32∗	−1.20∗	−2.33∗	−1.12∗
IL1B	−1.59∗	−1.32∗	−1.10∗	−1.38∗	−1.72∗
IL1R1	−1.10∗	−1.00∗	−1.19∗	−2.50∗	−1.30∗
IL-2	−1.00∗	−1.74∗	−1.14∗	−1.58∗	−1.28∗
IL-6	−2.46∗	−1.52∗	−5.61∗	−3.82∗	−2.48∗
IL-10	−4.06∗	−3.07∗	−4.67∗	−2.81∗	−2.88∗
IL-15	−1.03∗	−1.44∗	−1.09∗	−2.11∗	−1.19∗
TF	−2.10∗	−1.54∗	−1.34∗	−3.42∗	−1.67∗
MAPK8	−1.11∗	−1.03∗	−1.09∗	−1.03∗	−1.13∗
MX1	−1.51∗	−1.01∗	−1.52∗	−2.99∗	−1.31∗
NFKBIA	−1.13∗	−1.00∗	−1.16∗	−1.06∗	−1.13∗
LYZ	−1.59∗	−1.80∗	−1.63∗	−4.51∗	−1.78∗
TLR3	−1.21∗	−1.06∗	−1.16∗	−2.66∗	−1.09∗
TLR5	−1.19∗	−1.21∗	−1.27∗	−1.67∗	−1.52∗
HMBS	−1.27∗	−1.23∗	−1.54∗	−1.13∗	−1.23∗

∗Indicates fold change values that are significantly different compared with control (P < 0.05), ǀFCǀ ≥ 1.2.

¹Basal diet supplemented with bacitracin (BACI, 55 ppm), cranberry pomace at 1% (CP1) and 2% (CP2), and cranberry pomace ethanolic extract at 150 (COH150) and 300 ppm (COH300).

²Fold change (upregulation as a positive value or downregulation as a negative value) of genes in birds supplemented with 5 different feed treatments compared with control.