. 2020 Nov 5;100(2):797–809. doi: 10.1016/j.psj.2020.10.040

Table 7.

Effect of dietary aflatoxin B₁ (AFB) or ochratoxin A (OTA) contamination with or without berberine (BBR) supplementation on serum blood biochemistry at 42 d of age.

Treatment	CR (mg/dL)	UR (mg/dL)	AST (mg/dL)	ALT (mg/dL)	GGT (mg/dL)	MDA (U/mg protein)	SOD (U/mg protein)	GPX (U/mg protein)
NC¹	0.270^e	4.00^b	183.25^c	7.25^c	17.15^c	2.08^c	248.75^a	48.00^a
PCAFB¹	0.347^a,b	6.00^a	280.30^a	11.50^a	30.30^a	2.35^a	217.50^c	28.75^d
PCOTA¹	0.380^a	5.50^a,b	264.17^a	12.25^a	27.30^a,b	2.33^a	220.00^b,c	27.25^d
PCAFB+200 BBR²	0.340^a,b,c	4.50^a,b	230.70^b	9.75^a,b,c	24.60^b	2.27^a,b	228.25^b,c	30.00^c,d
PCAFB+400 BBR²	0.345^b,c,d,e	4.25^b	196.07^c	8.08^b,c	20.17^c	2.23^a,b	227.00^b,c	31.50^c,d
PCAFB+600 BBR²	0.287^c,d,e	4.26^b	183.90^c	7.50^b,c	17.47^c	2.17^b,c	227.75^b,c	38.00^b
PCOTA+200 BBR²	0.330^a,b,c,d	5.25^a,b	196.87^c	10.25^a,b	24.17^b	2.28^a,b	221.75^b,c	30.50^c,d
PCOTA+400 BBR²	0.305^b,c,d,e	4.25^b	189.72^c	8.05^b,c	19.72^c	2.24^a,b	226.75^b,c	31.75^c,d
PCOTA+600 BBR²	0.282^d,e	4.09^b	186.97^c	8.00^b,c	19.47^c	2.23^a,b	230.00^b	35.00^b,c
P-Value	0.0001	0.0001	0.0001	0.0001	0.0009	0.0001	0.0005	0.0001
SEM	0.011	0.0346	4.714	0.585	0.79	0.02	2.52	1.21

^a–eSuperscripts within columns indicate significant differences between treatments (P < 0.05).

Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; CR, creatinine; GGT, gamma-glutamyl transferase; GPX, glutathione peroxidase; MDA, malondialdehyde; SOD, superoxide dismutase; UR, urea.

NC, negative control diet with no additives; PCAFB, NC + 2 ppm AFB (positive control AFB); PCOTA, NC + 2 ppm OTA (positive control OTA).

Berberine supplementation (mg/kg diet).