. 2020 Nov 25;15(2):407–428. doi: 10.1002/1878-0261.12823

Table 2.

Differential metabolites tentatively identified in Mel1 patient‐derived cell line exosomes based on MS/MS fragmentation spectra and database search. m/z, mass‐to‐charge ratio; RT, retention time (min).

m/z	RT	Tentative ID ^a	Molecular formula ^b	Mass error ^c	P‐value ^d	FC ^e	IL ^f
496.3381	11.61	LPC (16:0)	C₂₄H₅₀NO₇P	3	6.48 × 10⁻⁵	4.1367 (↑)	2
515.3962	15.72	TG(18:2/22:3/22:4)	C₆₅H₁₀₈O₆	0	0.04258	2.2071 (↑)	2
729.5293	15.71	PG(20:0/12:0)	C₃₈H₇₅O₁₀P	4	0.04517	2.2063 (↑)	2
745.5143	15.70	PS(P‐16:0/15:1)	C₃₇H₇₀NO₉P	2	0.04205	2.2513 (↑)	2

^{^a}

Common name of the tentatively identified metabolite according to MS/MS fragmentation spectra and database search.

^{^b}

Molecular formula of the tentatively identified metabolite.

^{^c}

Mass error (p.p.m.).

^{^d}

P‐value corresponding to univariate statistical analyses (t‐test). Only peaks with a P‐value < 0.05 were selected.

^{^e}

Fold change expressed as the ratio of the two averages (AD/S2). Only peaks with a fold change > 1.5 or < 0.66 were selected. The arrows indicate whether the metabolite is increased (↑) or decreased (↓) in AD relative to S2.

^{^f}

Identification level: (1) molecular formula matched in compound databases and (2) experimental fragmentation spectrum matched in spectral databases.