Table 3b:

Grade 3 or higher treatment related adverse events over three treatment lines and by treatment line.

Event	All lines (n = 68)	1L (n = 68 )	2L (n = 53)	3L (n = 25)
Adverse Event
Fatigue	9 (13%)	3 (4%)	3 (6%)	4 (16%)
Anorexia	1 (1%)	--	1 (2%)	--
Infection	3 (4%)	2 (3%)	1 (2%)	--
Nausea/vomiting	6 (9%)	4 (6%)	2 (4%)	--
Diarrhea	3 (4%)	--	3 (6%)	--
Hematologic Toxicity
Neutropenia	12(18%)	6(9%)	4(8%)	3(12%)
Anemia	11 (16%)	7 (10%)	2 (4%)	3 (12%)
WBC decreased	6 (9%)	1 (1%)	2 (4%)	3 (12%)
Thrombocytopenia	4 (6%)	4(6%)