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. 2021 Jan 21;8:616972. doi: 10.3389/fcell.2020.616972

Figure 1.

Figure 1

Important role of m6A regulators in ccRCC. (A) Exploring (Meta-cohort) and verifying (GSE-cohort) different mRNA expression of 21 m6A regulators between normal and tumor samples in ccRCC. (B) 10-fold cross-validated error for LASSO analysis. First vertical line equals minimum error, whereas second vertical line shows cross-validated error within one standard error of minimum. (C) Profile of coefficients in model at varying levels of penalization plotted against log (lambda) sequence. (D) ROC curve of diagnostic score in training cohort. (E,F) ROC curves of diagnostic score in validation cohorts (GSE-cohort and TCGA-cohort). m6A, N6-methyladenosine; ccRCC, clear-cell renal cell carcinoma; LASSO, least absolute shrinkage and selection operator; ROC, receiver operating characteristic; TCGA, The Cancer Genome Atlas.