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. 2021 Jan 21;9:617225. doi: 10.3389/fcell.2021.617225

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Copyright © 2021 Ge, Li, Sun, Xin, Zhu, Liu, Tang, Han, Huang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Genomic instability in oocytes from obese mice. (A) Chromosome spread of MII oocytes obtained from ND and HFD mice (n = 56 ND oocytes from 3 mice and n = 47 HFD oocytes from 4 mice). Purple, kinetochores stained with CREST antibody; Blue, chromosomes stained with DAPI. Representative confocal images show the euploidy in ND oocytes and aneuploidy in HFD oocytes. (B) Summary of the frequency of aneuploidy in ND and HFD oocytes.