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. 2021 Feb 3;11:2961. doi: 10.1038/s41598-021-82483-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Patterns of AMG staining in the adrenal medulla. (a) Small dense black AMG granules, either adjacent to nuclei (filled arrow) or within the cytoplasm (open arrow), are present in fewer than 25% of these chromaffin cells (69 year-old male). (b) Black AMG granules, either large (filled arrow) or small (open arrow), often multiple, are present in the cytoplasm of more than 25% of chromaffin cells (32 year-old male). (c) Black AMG staining is present in most chromaffin cells, either as small grains dispersed in the cytoplasm (open arrow), or as these small grains accompanied by dense granules (filled arrow) (39 year-old male). AMG and hematoxylin.