Table 4.
Correlation between number of lifetime sexual partners, rates of HPV infection and high-grade cervical disease (CIN2 or worse).
| Number of lifetime sexual partners | n | (%pos) | Univariate | Multivariate | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Model 1 | Model 2 | Model 3 | |||||||||||||
| OR | (95% CI) | P value | aOR | (95% CI) | P value | aOR | (95% CI) | P value | aOR | (95% CI) | P value | ||||
| High-risk HPVa | 1 | 19/526 | (3.6) | Reference | – | Reference | – | Reference | – | Reference | – | ||||
| 2–5 | 150/1670 | (9.0) | 2.6 | (1.6–4.3) | < 0.01 | 3.1 | (1.9–5.0) | < 0.01 | 3.0 | (1.8–4.9) | < 0.01 | 3.3 | (2.0–5.4) | < 0.01 | |
| 6–9 | 117/580 | (20.2) | 6.7 | (4.1–11.1) | < 0.01 | 8.5 | (5.1–14.1) | < 0.01 | 8.0 | (4.8–13.4) | < 0.01 | 9.3 | (5.4–16.1) | < 0.01 | |
| ≥ 10 | 114/455 | (25.1) | 8.9 | (5.4–14.8) | < 0.01 | 10.4 | (6.3–17.4) | < 0.01 | 9.4 | (5.5–16.0) | < 0.01 | 11.3 | (6.4–19.9) | < 0.01 | |
| P for trend | < 0.01 | < 0.01 | < 0.01 | < 0.01 | |||||||||||
| HPV16/18 | 1 | 1/526 | (0.2) | Reference | – | Reference | – | Reference | – | Reference | – | ||||
| 2–5 | 18/1670 | (1.1) | 6.0 | (0.8–44.8) | 0.08 | 7.1 | (0.9–53.3) | 0.06 | 7.3 | (1.0–55.0) | 0.05 | 9.1 | (1.2–69.3) | 0.03 | |
| 6–9 | 33/580 | (5.7) | 35.3 | (4.8–259.2) | < 0.01 | 46.8 | (6.3–345.2) | < 0.01 | 50.2 | (6.8–373.3) | < 0.01 | 77.6 | (10.0–600.0) | < 0.01 | |
| ≥ 10 | 24/455 | (5.3) | 34.5 | (4.7–256.4) | < 0.01 | 42.1 | (5.7–313.6) | < 0.01 | 46.6 | (6.1–354.2) | < 0.01 | 78.7 | (9.9–628.2) | < 0.01 | |
| P for trend | < 0.01 | < 0.01 | < 0.01 | < 0.01 | |||||||||||
| HPV16/18/31/33/45/52/58 | 1 | 5/526 | (1.0) | Reference | – | Reference | – | Reference | – | Reference | – | ||||
| 2–5 | 82/1670 | (4.9) | 5.4 | (2.2–13.5) | < 0.01 | 6.4 | (2.6–16.0) | < 0.01 | 6.3 | (2.5–15.7) | < 0.01 | 7.2 | (2.9–18.1) | < 0.01 | |
| 6–9 | 70/580 | (12.1) | 15.0 | (6.0–37.4) | < 0.01 | 19.5 | (7.8–49.0) | < 0.01 | 18.5 | (7.3–46.9) | < 0.01 | 23.6 | (9.0–61.5) | < 0.01 | |
| ≥ 10 | 74/455 | (16.3) | 21.3 | (8.5–53.2) | < 0.01 | 25.6 | (10.2–64.1) | < 0.01 | 23.3 | (9.1–59.4) | < 0.01 | 31.4 | (11.8–83.3) | < 0.01 | |
| P for trend | < 0.01 | < 0.01 | < 0.01 | < 0.01 | |||||||||||
| CIN2 or worse | 1 | 0/526 | (0.0) | 0.0 | 0.99 | 0.0 | 0.99 | 0.0 | 0.99 | 0.0 | 0.99 | ||||
| 2–5 | 16/1670 | (1.0) | Reference | – | Reference | – | Reference | – | Reference | - | |||||
| 6–9 | 13/580 | (2.2) | 2.4 | (1.1–5.0) | 0.02 | 2.5 | (1.2–5.2) | 0.02 | 2.4 | (1.1–5.1) | 0.02 | 2.4 | (1.1–5.4) | 0.03 | |
| ≥ 10 | 18/455 | (4.0) | 4.4 | (2.2–8.8) | < 0.01 | 4.4 | (2.2–8.7) | < 0.01 | 4.2 | (2.0–8.8) | < 0.01 | 4.1 | (1.9–9.2) | < 0.01 | |
| P for trend | < 0.01 | < 0.01 | < 0.01 | < 0.01 | |||||||||||
CIN cervical intraepithelial neoplasia, OR odds ratio, aOR adjusted odds ratio.
Model 1 adjusted for age.
Model 2 adjusted for age and smoking history.
Model 3 adjusted for age, smoking history and age at first intercourse.
aHPV16/18/31/33/35/39/45/51/52/56/58/59/68 (HC2).