Table 5.
Risk factors for high-grade cervical disease (CIN2 or worse).
| CIN2 or worse | n | (%pos) | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|---|---|
| aOR | (95% CI) | P value | aOR | (95% CI) | P value | |||
| HPV type-specific infection | ||||||||
| Negative | 7/2925 | (0.2) | Reference | – | Reference | – | ||
| HPV16/18 | 13/76 | (17.1) | 126.1 | (47.9–331.9) | < 0.01 | 113.7 | (40.8–316.9) | < 0.01 |
| Other high-risk HPVa | 27/230 | (11.7) | 78.5 | (33.6–183.5) | < 0.01 | 65.9 | (27.1–160.2) | < 0.01 |
| Age at first intercourse | ||||||||
| ≤ 14 | 5/109 | (4.6) | Reference | – | Reference | – | ||
| 15–16 | 17/779 | (2.2) | 0.4 | (0.2–1.2) | 0.09 | 0.4 | (0.1–1.4) | 0.16 |
| 17–19 | 19/1441 | (1.3) | 0.3 | (0.1–0.7) | 0.01 | 0.4 | (0.1–1.4) | 0.15 |
| ≥ 20 | 6/902 | (0.7) | 0.1 | (0.0–1.4) | < 0.01 | 0.4 | (0.1–1.7) | 0.19 |
| Number of lifetime sexual partners | ||||||||
| 1 | 0/526 | (0.0) | 0.0 | 0.99 | 0.0 | 0.99 | ||
| 2–5 | 16/1670 | (1.0) | Reference | – | Reference | – | ||
| 6–9 | 13/580 | (2.2) | 2.4 | (1.1–5.0) | 0.02 | 0.8 | (0.4–1.9) | 0.68 |
| ≥ 10 | 18/455 | (4.0) | 4.4 | (2.2–8.8) | < 0.01 | 1.5 | (0.7–3.6) | 0.32 |
CIN cervical intraepithelial neoplasia, aOR adjusted odds ratio.
Adjusted for age, smoking history, age at first intercourse, number of lifetime sexual partners, HPV type-specific infection.
aHPV31/33/35/39/45/51/52/56/58/59/68.