Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jan 21;10:553628. doi: 10.3389/fonc.2020.553628

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Dong, Lv, Gu, Zhang and Ye

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

LAGE3 promoted proliferation and suppressed apoptosis of TNBC cell lines. (A) Box-and-whisker plot showing the expression of LAGE3 in various subtypes of BCs. (B, C) Protein and transcriptional level of LAGE3 in non-malignant MCF-10A cells and various BC cell lines. (C, D) Protein and mRNA level of LAGE3 in TNBC cell lines transfected with either negative control (si-NC) and LAGE3 targeting siRNA (si-LAGE3-1 or si-LAGE3-2). (E, F) Colony formation assay and (G) CCK-8 assay was showing the proliferation of cells transfected with si-NC or si-LAGE3. (H) Flow cytometry assay showing the number of apoptotic cells in different groups. Multiple groups were compared using unpaired Student’s t-test (two‐tailed). *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.