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. 2021 Jan 21;11:606441. doi: 10.3389/fimmu.2020.606441

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Copyright © 2021 Kahalehili, Newman, Pennington, Kolluri, Kerkvliet, Shulzhenko, Morgun and Ehrlich

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dietary I3C exacerbates insulitis in NOD mice. (A) Schematic of experimental design. From 7 to 12 weeks of age, NOD mice were maintained on a synthetic AhR ligand-free diet or diet supplemented with 2,000 ppm I3C. Stool samples were collected at 7, 8, and 12 weeks of age (at the time of sacrifice). Food consumption (B) and body weight (C) were measured weekly. (D) In two independent experiments, insulitis was scored as no infiltration, less than 50%, and greater than 50% of islets infiltrated. Data are presented as the average from each mouse per group. Experiment 1: n = 9 mice/group; Experiment 2: n = 7–8 mice/group. *p < 0.05.