FIGURE 1.

Selection pressure acting on B. pseudomallei population. The histogram summarizes ranges of dN/dS calculated from predicted coding sequences from a collection of diverse B. pseudomallei population from northeast Thailand (Chewapreecha et al., 2019), and B. thailandensis genomes from the public database. B. pseudomallei and B. thailandensis have highly plastic genomes comprising of at least two chromosomes of ∼7–8Mb in size when combined. Using a pan-genome approach, all coding sequences could be categorized as “core” (present in all genomes) or “accessory” (variably present across studied genomes). Accessory genes display an elevated level of dN/dS which is signatures of positive selection or more relaxed purifying selection.