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. 2020 Nov 16;11(1):293–299. doi: 10.1007/s13555-020-00464-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 1 — Myofibroblast properties [13]. Reprinted with permission from van Caam A, et al. Unraveling SSc Pathophysiology; The Myofibroblast. Front Immunol. 2018;9:2452. Published 2018 Nov 13. 10.3389/fimmu.2018.02452. Myofibroblasts produce ECM factors and contain contractile stress fibers comprising of α-SMA. They are closely associated to neighboring cells and the ECM within their environment through focal adhesions and adherens junctions. α-SMA alpha-smooth muscle actin; CTGF connective tissue growth factor; ECM extracellular matrix; EDA extra domain A; FAK focal adhesion kinase; IL interleukin; LH2 lysyl hydroxylase-2; PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2; RGD arginylglycylaspartic acid; TGFβ transforming growth factor β; VEGF vascular endothelial growth factor