Fig. 2.

Hormone effects on skin vary by race. A total of 116 subjects were assessed (CEE n = 38; E2 n = 34; Placebo n = 44; White n = 77; Black n = 21; Other n = 16) the average age at menopause was 53.2 ± 2.8 years, the average time since menopause was 1.6 ± 1.1 years and the average BMI (kg/m²) was 26.0 ± 4.1. Reproduced with permission from [65]. a Mean total wrinkle score by treatment and by race over 4 years of follow-up. Racial groups (white and black) stratified by treatment group are indicated by gray and black lines, respectively. Total wrinkle score was not significantly different among treatment groups at any time point (P = 0.24). Black women, compared with White women, had the lowest total wrinkle scores across all 4 years (P = 0.002). b Men total rigidity score by treatment and by race over 4 years of follow-up. Racial groups (White and Black) stratified by treatment group indicated by gray and black lines, respectively. Total rigidity did not vary significantly among treatment groups at any time point (P = 0.87). Black women, compared with White women, had significantly decreased total facial rigidity after 4 years of follow-up (P = 0.002)