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. 2021 Jan 8;97(1):1–21. doi: 10.2183/pjab.97.001

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© 2021 The Japan Academy

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — An action of edonerpic maleate (T-817MA) and its efficacy on motor function recovery after brain damage. (A) Facilitation of edonerpic maleate on training (and experience)-dependent synaptic GluA1-contaning AMPAR trafficking. Edonerpic maleate-CRMP2 complex dephosphorylates ADF/cofilin, which activates ADF/cofilin and promotes AMPAR trafficking to post-synaptic membranes, presumably via an increase in actin turnover. (B) In reach-to-grasp task with mice, edonerpic maleate augments motor function recovery after brain damage in a training-dependent manner. Edonerpic maleate facilitates the synaptic trafficking of GluA1-containing AMPARs in a peri-injured region. (C) In a non-human primate, edonerpic maleate drastically promotes dexterity of a paralytic upper limb after internal capsule hemorrhage. This derives from Ref. 7.