Figure 5.

Diagnosis and therapeutic scheme for AMPAR-related diseases. The levels of synaptic AMPAR can be altered under disease conditions. This synaptic disease status can be monitored with AMPA-PET imaging ([¹¹C]K-2): “See the disease”. Effective therapeutic interventions such as drugs and mechanical manipulations can restore the levels of synaptic AMPAR to a normal level, thereby reaching remission status. DBS: deep brain stimulation, ECT: electroconvulsive therapy, TMS: transcranial magnetic stimulation.