Table 1.
Clinical trials and studies with [11C]K-2
| Trial title | Trial number | Type of disease |
|---|---|---|
| Clinical trial to evaluate the efficacy and safety of [11C]K-2 in healthy volunteers | UMIN000020975 | Healthy volunteers |
| The clinical trial to evaluate the efficacy of [11C]K-2 in refractory epilepsy patients undergoing anterior temporal lobectomy | UMIN000025090 | Refractory epilepsy patients |
| The clinical pilot study to examine the distribution of [11C]K-2 in depression, bipolar disease, schizophrenia, addiction, ASD, epilepsy, and FTD patients in order to develop a novel diagnostic method in cross-sectional way toward these diseases | UMIN000025132 | Mental disease/ Healthy volunteers |
| Clinical trial to examine the effective dose and safety of [11C]K-2 synthesized using a dedicated machine in healthy male volunteers | UMIN000026357 | Healthy volunteers |
| The exploratory clinical trial to evaluate the efficacy of [11C]K-2 in stroke patients under rehabilitation | UMIN000029952 | Stroke |
| Clinical trial to examine the densities of AMPA receptors in epilepsy patients with [11C]K-2 | UMIN000031624 | Epilepsy patients |
| Clinical trial to examine the effectiveness of AMPA-PET to identify an epileptogenic focus in refractory epilepsy patients | JapicCTI-194576 | Refractory epilepsy patients |
| Investigator-initiated clinical trial to evaluate the efficacy of AMPA-PET in functional recovery process by rehabilitation for subjects registered in the clinical phase II trial of T-817MA (T817MAJP201R trial) | JapicCTI-194711 | Stroke |
| The relationship of AMPA receptor density with presence or absence of subsequent onset in high-risk cases of psychosis: A longitudinal PET study using [11C]K-2 | jRCTs031190151 | ARMS |
| The relationship of AMPA receptor density in patients with autism spectrum disorder: A transversal PET study using [11C]K-2 | jRCTs031190149 | ASD |
| The relationship of AMPA receptor density in patients with depression and bipolar disorder: A transversal PET study using [11C]K-2 | jRCTs031190150 | Depression/Bipolar |
| The relationship of AMPA receptor density in patients with schizophrenia: A transversal PET study using [11C]K-2 | jRCTs031190197 | Schizophrenia |
| A pilot study to validate the estimate of accuracy between standard uptake value ratio and non displaceable binding potential obtained from [11C]K-2 PET imaging in major cognitive disorders | jRCTs031190262 | Major cognitive disorders |
| A transversal PET study using [11C]K-2 to investigate age-and-sex-related changes in AMPA receptor density in healthy volunteers | jRCTs031200083 | Healthy volunteers |