TABLE 2.
Characteristics of the participants with CSF samples.
| Characteristics | Controls (n = 76) | AD (n = 35) | p-value |
| Age, mean (SD), y | 68.42 (8.52) | 66.34 (1.47) | 0.240 |
| Female, n (%) | 46 (60.5) | 18 (51.43) | 0.412 |
| Education level, mean (SD), y | 9.24 (4.36) | 9.63 (3.80) | 0.652 |
| MMSE score, mean (SD) | 26.28 (3.05) | 12.03 (4.08) | <0.001 |
| APOE ε4 carriers, No (%) | 8 (10.53) | 14 (40.00) | 0.001 |
| Diabetes, (%) | 11 (14.47) | 6 (17.14) | 0.779 |
| Hypertension, (%) | 19 (25.00) | 8 (22.86) | 0.819 |
| Dyslipidaemia, (%) | 21 (27.63) | 11 (31.43) | 0.822 |
| Coronary artery disease, (%) | 13 (17.11) | 7 (20.00) | 0.792 |
| Stroke history, (%) | 6 (7.89) | 2 (5.71) | 0.726 |
| CSF Aβ40, mean (SD), pg/mL | 12190 (4482) | 9150 (3926) | 0.001 |
| CSF Aβ42, mean (SD), pg/mL | 1508 (673.2) | 629.5 (286.5) | <0.001 |
| CSF t-tau, mean (SD), pg/mL | 184.0 (61.38) | 402.3 (183.6) | <0.001 |
| CSF p-tau, mean (SD), pg/mL | 42.84 (18.18) | 66.09 (28.38) | <0.001 |
| CSF t-tau/Aβ42, mean (SD), pg/mL | 0.146 (0.080) | 0.8867 (0.672) | <0.001 |
| CSF p-tau/Aβ42, mean (SD), pg/mL | 0.0334 (0.0206) | 0.1317 (0.0844) | <0.001 |
MMSE, mini-mental state examination; APOE ε4, apolipoprotein E ε4 allele; p-value, two-tailed independent t-tests, Mann–Whitney U test or Chi-square test as appropriate.