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Hexamer structure of tenascin-C (TNC; upper), monomer structure of TNC (lower), and the possible downstream signaling pathway in stroke. Six TNC monomers combine to a hexamer at their N-terminal domains. EGF, epidermal growth factor; ERK1/2, extracellular signal-regulated kinase 1/2; JNKs, c-Jun N-terminal kinases; MMP-9, matrix metalloproteinase-9; TLR4, Toll-like receptor 4.
