Figure 5.

Analysis of human proteins in skin tissue inoculated with M. sympodialis. Human proteins with higher levels in tissue at day 6 post-infection (≥2 fold change compared to their corresponding non-inoculated control: non-OA, OA) were analyzed by gene ontology. Statistical analysis was done by Fisher’s test with FDR correction (p value). (A) biological processes in M. sympodialis-inoculated skin, circles are 1) antimicrobial response, 2) cornification 3) defense response to fungus. (B) processes in skin co-inoculated with M. sympodialis and oleic acid, circles are 1) removal of superoxide radicals, 2) chylomicron remodeling. (C, D) show proteins with significantly increased levels in each condition. Fold change was estimated relative to protein level in non-inoculated skin without OA.