Table 1.
| Topical anti-inflammatory agents | Strength (%) | Formulation | Recommended usage |
|---|---|---|---|
| Topical calcineurin inhibitors | |||
| Pimecrolimus | 1a | Cream |
Control of mild-to-moderate acute flares on sensitive skin and other body areas Intermittent use on sensitive skin and other body areas |
| Tacrolimus | 0.03b, 0.1c | Ointment |
Control of moderate-to-severe acute flares on body areas other than face/flexures/other sensitive skin Proactive use on non-sensitive skin |
| Topical corticosteroids | |||
| Class 7 | |||
| Dexamethasone | 0.1 | Cream | Control of mild acute flares on non-sensitive skin |
| Hydrocortisone | 0.25, 0.5, 1 | Cream/ointment/lotion/solution | |
| Hydrocortisone acetate | 0.5–1 | Cream/ointment | |
| Class 6 | |||
| Fluocinolone acetonide | 0.01 | Cream/solution | Control of mild-to-moderate acute flares on non-sensitive skin |
| Desonide | 0.05 | Cream/gel/foam/ointment | |
| Alclometasone dipropionate | 0.05 | Cream/ointment | |
| Class 5 | |||
| Hydrocortisone valerate | 0.2 | Cream/ointment | Control of mild-to-moderate acute flares on non-sensitive skin |
| Hydrocortisone probutate | 0.1 | Cream | |
| Hydrocortisone butyrate | 0.1 | Cream/ointment/solution | |
| Class 3–4 | |||
| Triamcinolone acetonide | 0.1 | Cream/ointment | Control of mild-to-moderate acute flares on non-sensitive skin |
| Mometasone furoate | 0.1 | Cream | |
| Fluticasone propionate | 0.05 | Cream/ointment | |
| Fluocinolone acetonide | 0.025 | Cream/ointment | |
| Betamethasone valerate | 0.1 | Cream/foam/lotion/ointment | |
| Class 2 | |||
| Triamcinolone acetonide | 0.5 | Cream/ointment | Control of moderate-to-severe acute flares on non-sensitive skin (limited duration of use: < 2 weeks) |
| Mometasone furoate | 0.1 | Ointment | |
| Fluocinonide | 0.05 | Cream/gel/ointment/solution | |
| Betamethasone dipropionate | 0.05 | Cream/foam/ointment/solution | |
| Amcinonide | 0.1 | Cream/lotion/ointment | |
| Class 1 | |||
| Diflorasone diacetate | 0.05 | Ointment | Control of severe acute flares on non-sensitive skin (limited duration of use: < 2 weeks) |
| Clobetasol propionate | 0.05 | Cream/foam/ointment | |
Table is adapted from Chow et al. [36]. Some of the agents listed in table may not be available in all Asian countries
aInfants aged 3 months to 2 years (Australia [41], Brazil [42], India [43], Indonesia [49], Israel [45], New Zealand [46], Philippines [47], Russia [48], Thailand [44] only; use in infants off-label elsewhere); children aged ≥ 2 years, adolescents, and adults. Pimecrolimus is not available for use in Japan
bChildren aged ≥ 2 years and adolescents aged < 16 years
cAdolescents aged ≥ 16 years and adults