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. 2020 Nov 5;11(3):857–880. doi: 10.1016/j.jcmgh.2020.10.015

Figure 10.

Figure 10

Pharmaceutical inhibition of CXCR2 attenuates gastric mucosa senescence and atrophy in vivo. (A) Diagram showing the protocol of the mouse study. (B) Colonization of H pylori in different groups assessed by histology score. (C) Neutrophil infiltration score in different groups. Left: Representative H&E images are shown. Black arrows: neutrophils. Scale bar: 100 μm. (D) Upper: Senescent cells detected using SA-β-gal staining in mouse gastric mucosa in different groups. Lower: Representative images of mouse stomachs. Scale bar: 50 μm. Plot: median. Significant differences were analyzed using the Mann–Whitney test. All histology images were taken from the antrum or the junction between the antrum and corpus. ∗P < .05. ∗∗P < .01. ∗∗∗∗P < .0001. NFR, nuclear fast red; SB, SB225002.