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. 2021 Feb 3;11:2972. doi: 10.1038/s41598-021-82533-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The PPI of the leading edge in the up-regulated gene-sets in AF. The PPI of each leading edge and their expression profile (heatmap) that were derived from (a) Response to bacterium, or (b) Oxidative phosphorylation and Carboxylic acid catabolic process. Among each gene-set, functionally grouped nodes (proteins) are encircled with its corresponding GO terms. Only the proteins with non-adjusted p-value < 0.1 are displayed here. The color of the nodes and the edges represent the non-adjusted p-value (0–0.1) and the STRING combined score (0.4–1.0), respectively. The color scale of expression represents the z-score of normalized spectral counts of each protein (shown as its gene name in each heatmap). The heatmaps were generated using R software⁵⁴ (version 3.5.3).