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. 2021 Jan 21;8:622793. doi: 10.3389/fcell.2020.622793

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Copyright © 2021 Liu, Zhang, Kan, Wang, Liu, Gong and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NKAP specific function in neuroblastoma cells via activated PI3K/AKT pathway. Transfected with siNKAP significantly reduced the phosphorylations of PI3K and AKT in NB1 (A) and SK-N-SH (B) cells in vitro. (C) Gene Set Enrichment Analysis. Activation of the PI3K/AKT pathway transfected with siNKAP did not reduce the expression of p-PI3K and p-AKT in SK-N-SH cells (D), transfected with siNKAP did not promote the apoptosis of SK-N-SH cells (E), and transfected with siNKAP did not inhibit the proliferation of SK-N-SH cells (F). ***P < 0.001, **P < 0.01, *P < 0.05.