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. 2021 Jan 21;14:593263. doi: 10.3389/fncir.2020.593263

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Copyright © 2021 Sendi, Zendehrouh, Miller, Fu, Du, Liu, Mormino, Salat and Calhoun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation between FNC of each state and clinical score. A significant negative correlation between within-SCN, within-SMN, within-VSN, and within-CBN connectivity and the clinical dementia rating scale sum of boxes (CDR-SOB) scores. A disrupted pattern (i.e., both positive and negative) correlation was found between within-CCN and within DMN with CDR-SOB. A similar disrupted pattern was observed between CDR-SOB and between-networks connectivity. However, we consistently observed negative connectivity between CDR-SOB and the connectivity among sensory networks. The color bar shows the strength of the connectivity. SCN, subcortical network; ADN, auditory network; SMN, sensorimotor network; VSN, visual network; CCN, cognitive control network; DMN, default-mode network; and CBN, cerebellar network. The significant correlation that passes the multiple comparisons is marked by asterisks.