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. 2021 Jan 21;14:593263. doi: 10.3389/fncir.2020.593263

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Copyright © 2021 Sendi, Zendehrouh, Miller, Fu, Du, Liu, Mormino, Salat and Calhoun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dynamic functional network connectivity in healthy control and patients. (A) The three identified dFNC states using the k-means clustering method in healthy control (HC). (B) Occupancy rate (OCR) of HC in each state. HCs have the highest OCR in state 2 (corrected p < 0.001). OCR of state 3 is higher than the OCR of state 1 in HC subjects (corrected p < 0.01). (C) The three identified dFNC states using the k-means clustering method in patients (vmAD). (D) Occupancy rate (OCR) of HC in each state. vmAD subjects have the highest OCR in state 2 (corrected p < 0.001). OCR of state 1 is higher than OCR of state 2 in patients (corrected p < 0.01). (E) Correlation between FNC of each state and clinical score in the only patient group. SCN, subcortical network; ADN, auditory network; SMN, sensorimotor network; VSN, visual network; CCN, cognitive control network; DMN, default-mode network; and CBN, cerebellar network. The significant correlation that passes the multiple comparisons is marked by asterisks.