Fig. 3.

Bioinformatics analysis of CpG island prediction on TERT gene promoter and interaction network using the STRING database. (A) TERT, and its strongly interacting protein interaction network derived from the STRING database. In a biological network, a node is any biological molecule and an edge indicates the interaction between the two nodes. (B) CpG island presence near the promoter of a gene is strongly associated with methylation mark recruitment. Our bioinformatics analysis provided the information that there is a heavy abundance of CpG island near the TERT gene promoter. As the TERT promoter contains a site for various transcription factors, these CpG islands may play a role in the alteration and regulation of TERT transcription. The location of the CpG islands is colored in light blue. TERT, Human Telomerase reverse transcriptase. TERT, human telomerase reverse transcriptase. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)