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. 2021 Feb 3;41(2):BSR20203413. doi: 10.1042/BSR20203413

Figure 1. B and T cells, origin and differentiation.

Figure 1

Stem cells in blood marrow differentiate in T or B lymphocyte, according to the presence of CD3 or CD19, respectively. Lymphocyte final maturation takes place in thymus for T cells; or in spleen and lymphatic tissue for classic B cells. B1 lymphocytes are well described in experimental studies. These cells are notorious for their capacity of spontaneous production of IgM and according to the presence of the CD11b, two distinct subtypes are recognized: CD11b- B1 lymphocytes, producing IgM, and CD11b+ B1 lymphocytes, related to the expansion of CD4+ T lymphocytes.