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. 2021 Jan 21;7:626140. doi: 10.3389/fmed.2020.626140

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Copyright © 2021 Xu, Li, Wang, Huang, Zhang, Zhang, Gu, Yu and Jia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cilomilast improved UUO-induced inflammatory responses. (A) qRT-PCR analyses of Il-6, Tnf-α, Il-18, Icam-1, and Mcp-1 mRNA expression (n = 6). (B) Representative images and quantitative assessment of the expression and distribution of F4/80 and TNF-α in kidney tissues using immunohistochemical staining. Scale bar = 20 μm. The data are presented as the mean ± SEM. Statistically significant differences were determined by two-way ANOVA. ^##P < 0.01, ^####P < 0.0001, *P < 0.05, ***P < 0.001, ****P < 0.0001.