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. 2021 Jan 21;14:593545. doi: 10.3389/fnins.2020.593545

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Copyright © 2021 Heinzel, Oberhauser, Keibl, Swiadek, Längle, Frick, Kolbenschlag, Prahm, Grillari and Hercher.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Evaluation of the degree of external paw rotation by measuring the Paw Angle Body Axis. This is the angle between the orientation of the front paw (A) and the animal's body axis (B). Note that both axes can be individually drawn by the experimenter analyzing the CatWalk (CW) data. (A) The white line defines the orientation of the paw. (B) The white line defines the animal's body axis. The red line defines the animal's body movement vector, which is calculated by linear regression of the animal's center of gravity in the recorded frame and in the three frames preceding it. The white cross indicates the orientation of the respective paw in relation to the rat's body axis; P, proximal; D, distal; M, medial; L, lateral.