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. 2021 Jan 21;9:630645. doi: 10.3389/fcell.2021.630645

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Copyright © 2021 Noueihed, Rivera, Dabouz, Abram, Omri, Lahaie and Chemtob.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Conditioned media (CM) of hypoxic MSC (MSCs-CM) promoted vascular growth in OIR retinas. (A) Representative photomicrographs from isolectin B4-stained retinal flatmounts from normoxic or OIR mice at P17 intravitreally treated with vehicle or MSCs-CM. Scale bar 500 μm. Retinas intravitreally injected with MSCs-CM demonstrate decreased VO (B) and NV (C) areas highlighted in yellow and white, respectively. Quantification of VO and NV is represented in the graphs (**p < 0.01 vs vehicle, values are mean ± SEM, n = 6–10 retinas).