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. 2021 Jan 21;8:613621. doi: 10.3389/fbioe.2020.613621

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Copyright © 2021 Hagen, Lehmann, Aurich, Bauer, Melzer, Moellerberndt, Patané, Schnabel and Burk.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A–C) Negative correlation of donor age with platelet (PLT; A), platelet-derived growth factor (PDGF-BB; B) and transforming growth factor (TGFB1; C) concentrations (p < 0.05 based on Spearman's rank correlation). (D–F) PLT (D), PDGF-BB (E), and TGFB1 (F) concentrations in EDTA whole blood or serum samples drawn directly from the donor horses, as well as in samples from different processing stages (replicate blood bags pooled for each animal), obtained from younger and older donors; pairwise comparisons between the samples from younger and older animals were performed (Mann-Whitney U-test; p-values are given for significant differences compared with the respective samples from the older age group). Data were obtained from n = 11 younger and n = 8 older horses.