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. 2021 Feb 3;12:779. doi: 10.1038/s41467-021-21022-9

Fig. 3. Gadolinium enhancement in T1-weighted.

Fig. 3

Immediately after the blood–brain barrier (BBB) opening procedure in patients 1–4 (BBB01). The BBB opening was closed after 24 h (stage 1) in patients 1, 3, and 4 (BBB01-24 h) and in patient 2 at the 7th day MR follow-up (BBB01-7d). For stage 2 treatment, BBB was closed in patients 1 and 2 and in the following MRI study in patients 3 and 4 (BBB02-7d).