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. 2021 Feb 3;11:2967. doi: 10.1038/s41598-021-82542-4

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© The Author(s) 2021, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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In vivo efficacy of MDM4 inhibition with an orthotopic xenograft murine model of HB. (a) Timeline of the animal study. (b) BLI and MRI images at early and late time points show progression of the HepT1-derived tumors in the placebo animals and animals treated with NSC207895. The cell line was stably transduced with luciferase to allow the use of BLI to monitor tumor growth in living animals. (c) Tumor weights of the placebo and NSC207895-treated animals at time of euthanasia. Kruskal Wallis test used to show significance. (d) Quantification of TUNEL staining of the tumors from the placebo and treatment animals. TUNEL-positive areas from images taken on a Keyence BZ-X710 All-in-One Fluorescence Microscope were quantified using the Keyence Hybrid Cell Count Analysis Application. Error bars represent SD. Student’s t test *P < 0.05, **P < 0.01, ***P < 0.001. (e) Representative pictures of H&E and TUNEL staining quantified in d. Scale bars represent 50 μm in 10X and 40X images.