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. 2021 Feb 3;12:757. doi: 10.1038/s41467-021-21026-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Comparison of somatic copy number alterations (SCNAs, panel (a)), COSMIC single-base substitution (SBS) signatures (panel (b)), and de novo indel signatures (panel (c)) in 11 paired primary tumor (P) and recurrence (R) samples (upper) as well as three paired tumor and metastasis samples (lower). R recurrence, LM lymph node metastasis, TM thoracic metastasis. d Shared proportion of SCNAs, single nucleotide variations (SNVs), and indels in 11 paired primary tumor and recurrence samples. Each bar indicates the proportion of alterations in primary tumor only (red), recurrence only (green), and shared between primary and recurrence samples (gray) within each patient. e Comparison of structural variants (SVs) in four paired primary tumor and recurrence samples with total number of SVs larger than 20. Number of SNVs (f) and indels (g) shared among R, LM, and TM samples. h Comparison of SVs among R, LM, and TM samples. See also Supplementary Fig. 8.