Skip to main content
. 2021 Feb 3;12:781. doi: 10.1038/s41467-021-20980-4

Fig. 5. Activation of propriospinal neurons that project from thoracic to lumbar levels elicits locomotor behavioural recovery after T8 crush.

Fig. 5

a Experimental schematic of the intersectional strategy of limiting hM3Dq expression to propriospinal neurons projecting to lumbar spinal cord. b Stickviews of kinematic analysis of intact mice and injured mice with targeted expression of hM3Dq in long-projecting neurons before and during CNO (1 mg/kg). The phases of dragging, stance, or swing were marked in indicated colours. Data from intact mice are replotted from Fig. 2c for comparison. c BMS scores of mice with targeted expression of hM3Dq in long-projecting neurons at 4 and 8 weeks after injury, before and 1 h after application of 1 mg/kg CNO. Data shown as mean ± SD. Two tailed paired t test. **p = 0.0002 (4 weeks) ***p < 0.0001 (8 weeks). n = 7 (4 weeks) and n = 3 (8 weeks). Quantification of the maximum iliac crest heights (d) and the maximum toe height (e). n = 6 (intact) and n = 5 (hM3Dq). Data from intact mice are replotted from Fig. 2e, f for comparison. Shown are means ± SD. Two tailed paired t test for within-group comparison (#) and two sample t test for between-group comparison (*). ##p = 0.0030, **p = 0.0003, ***p < 0.001 and #p = 0.0017.