Table 3.
Prognostic factors of recurrence-free-survival (RFS) for patients with narrow and wide margin resection.
| Variable | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P-Value | HR (95% CI) | P-Value | |
| Surgical margin (narrow/wide) | 0.504 (0.356–0.715) | <0.001 | 0.608 (0.414–0.893) | 0.011 |
| Age (≤60/>60 years old) | 0.850 (0.593–1.217) | 0.374 | ||
| Gender (male/female) | 0.724 (0.416–1.261) | 0.254 | ||
| HBs Ag (negative/positive) | 1.917 (1.200–3.062) | 0.006 | 2.159 (1.302–3.580) | 0.003 |
| Cirrhosis (no/yes) | 1.070 (0.726–1.579) | 0.732 | ||
| Alcohol consumption (no/yes) | 1.012 (0.714–1.435) | 0.946 | ||
| AFP (≤20/>20ng/ml) | 1.640 (1.144–2.351) | 0.007 | 1.413 (0.968–2.063) | 0.073 |
| ALT (≤40/>40U/L) | 1.904 (1.341–2.702) | <0.001 | 1.422 (0.973–2.076) | 0.069 |
| Child-Pugh class | 0.166 | |||
| A5 | Reference | |||
| A6 | 0.876 (0.444–1.725) | 0.701 | ||
| A7 | 2.970 (0.930–9.481) | 0.066 | ||
| Tumor size (≤5/>5cm) | 1.185 (0.835–1.683) | 0.341 | 0.845 (0.570–1.253) | 0.402 |
| No. of tumor (single/multiple) | 2.330 (1.535–3.536) | <0.001 | 1.281 (0.757–2.167) | 0.356 |
| Edmondson grades (I–II/III–IV) | 1.287 (0.872–1.900) | 0.204 | ||
| Tumor capsule (absent/present) | 0.394 (0.267–0.581) | <0.001 | 0.447 (0.290–0.691) | <0.001 |
| MVI classification | <0.001 | 0.003 | ||
| M0 | Reference | Reference | ||
| M1 | 1.800 (1.214–2.671) | 0.003 | 1.138 (0.693–1.868) | 0.611 |
| M2 | 3.364 (2.102–5.381) | <0.001 | 2.394 (1.382–4.147) | 0.002 |
| Unclear | 0.336 (0.047–2.429) | 0.280 | 0.233 (0.031–1.763) | 0.158 |
| Extent of liver resection (minor/major) | 2.005 (1.415–2.841) | <0.001 | 1.586 (1.070–2.351) | 0.022 |
| pTNM stage | <0.001 | 0.560 | ||
| I | Reference | Reference | ||
| II | 2.451 (1.611–3.729) | <0.001 | 1.487 (0.862–2.565) | 0.154 |
| III | 4.978 (2.378–10.420) | <0.001 | 1.475 (0.510–4.264) | 0.473 |
| IVA | 2.52 3(1.485–4.288) | 0.001 | 1.326 (0.691–2.547) | 0.396 |
| Postoperative TACE (no/yes) | 1.139 (0.769–1.686) | 0.517 | ||
Surgical resection, tumor number, tumor size, and variables with p value <0.01 in the univariable Cox analyses were retained for the multivariable Cox analysis. The foreparts of the parentheses were set as the reference groups in the univariable and multivariable Cox analysis.
HBs Ag, hepatitis B surface antigen; AFP, alpha-fetoprotein; ALT, alanine aminotransferase; MVI, microvascular invasion; pTNM stage, pathologic TNM stage; TACE, transcatheter arterial chemoembolization. P < 0.05 was indicated by bold values.