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. 2021 Jan 21;10:610636. doi: 10.3389/fonc.2020.610636

Table 4.

Prognostic factors of overall survival (OS) for patients with narrow and wide margin resection.

Variable Univariate analysis Multivariate analysis
HR (95% CI) P-Value HR (95% CI) P-Value
Surgical margin (narrow/wide) 0.366 (0.226–0.591) <0.001 0.518 (0.308–0.871) 0.013
Age (≤60/>60 years old) 0.960 (0.598–1.542) 0.866
Gender (male/female) 0.543 (0.235–1.252) 0.152
HBs Ag (negative/positive) 1.340 (0.747–2.402) 0.326
Cirrhosis (no/yes) 1.091 (0.646–1.843) 0.744
Alcohol consumption (no/yes) 0.923 (0.580–1.467) 0.734
AFP (≤20/>20ng/ml) 2.042 (1.237–3.374) 0.005 1.611 (0.949–2.735) 0.077
ALT (≤40/>40U/L) 2.374 (1.494–3.771) <0.001 1.941 (1.190–3.168) 0.008
Child-Pugh class <0.001 0.017
 A5 Reference Reference
 A6 1.966 (0.975–3.966) 0.059 1.898 (0.882–4.082) 0.101
 A7 8.140 (2.911–22.760) <0.001 4.150 (1.355–12.708) 0.013
Tumor size (≤5/>5cm) 1.603 (1.010–2.545) 0.045 0.897 (0.531–1.514) 0.683
No. of tumor (single/multiple) 1.985 (1.138–3.462) 0.016 0.856 (0.414–1.771) 0.675
Edmondson grades (I–II/III–IV) 1.616 (0.984–2.654) 0.058 1.335 (0.765–2.332) 0.309
Tumor capsule (absent/present) 0.325 (0.201–0.527) <0.001 0.421 (0.244–0.725) 0.002
MVI classification <0.001 <0.001
 M0 Reference Reference
 M1 2.437 (1.373–4.325) 0.002 1.269 (0.633–2.544) 0.501
 M2 7.194 (4.003–12.929) <0.001 5.031 (2.510–10.085) <0.001
Unclear 1.048 (0.141–7.784) 0.963 0.988 (0.123–7.929) 0.991
Extent of liver resection (minor/major) 2.440 (1.522–3.912) <0.001 1.437 (0.839–2.462) 0.187
pTNM stage <0.001 0.193
 I Reference Reference
 II 3.743 (1.955–7.167) <0.001 1.945 (0.874–4.326) 0.103
 III 12.758 (5.000–32.555) <0.001 4.547 (1.117–18.499) 0.034
 IVA 4.454 (2.081–9.529) <0.001 1.785 (0.722–4.416) 0.210
Postoperative TACE (no/yes) 0.921 (0.535–1.588) 0.768

Surgical resection, tumor number, tumor size, and variables with p value <0.01 in the univariable Cox analyses were retained for the multivariable Cox analysis. The foreparts of the parentheses were set as the reference groups in the univariable and multivariable Cox analysis.

HBs Ag, hepatitis B surface antigen; AFP, alpha-fetoprotein; ALT, alanine aminotransferase; MVI, microvascular invasion; pTNM stage, pathologic TNM stage; TACE, transcatheter arterial chemoembolization. P < 0.05 was indicated by bold values.