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. 2021 Jan 21;10:606790. doi: 10.3389/fonc.2020.606790

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Copyright © 2021 Zhou, Yang, Yan, Shi, Xiao, Wei, Jiang and Wu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Knockdown of LETM1 regulates autophagy and apoptosis through activating AMPK. (A, B) Western blot analysis of the expressions of autophagic associated proteins (Beclin1, p62, and LC3), apoptotic-related proteins (p-Bcl-2, Bcl-2, Bax, caspase-3), LETM1, and AMPK in LETM1-knockdown along with AMPK inhibitor Huh7 and QGY-7701 cell lines. ^#p < 0.05, ^##p < 0.01, ^###p < 0.001 means dorsomorphin versus LETM1 shRNA+dorsomorphin group; ^&p < 0.05, ^&&p < 0.01, means LETM1 shRNA group versus LETM1 shRNA+dorsomorphin group.