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. 2021 Jan 21;11:612396. doi: 10.3389/fendo.2020.612396

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Copyright © 2021 Şoica, Voicu, Ghiulai, Dehelean, Racoviceanu, Trandafirescu, Roșca, Nistor, Mioc and Mioc

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overview of the oncogenic signaling pathways targeted by triterpenoids in reproductive hormones-dependent cancers: breast cancer, prostate cancer, ovarian cancer and cervical cancer. The red bars represent an inhibitory effect whereas blue bars represent a stimulatory effect. ER, estrogen receptor; E, estrogen; ERE, estrogen response element; AR, androgen receptor; Cyt c, cytochrome c; ROS, reactive oxygen species; T, testosterone; DHT, dihydrotestosterone. A more detailed explanation regarding the antiproliferative mechanism of action of triterpenes, in each type of cancer, is explained in detail in the main text.