Table 1.

Triterpenoid compounds with reported in vitro antiproliferative activity.

Ring type	Basic structure	Vegetal specie	Cell line affected by its antiproliferative activity		IC50		Reference
	Tetracyclic triterpenoids
Cucurbitane		Momordica charantia	Human breast carcinoma MDA-MB-231 and MCF-7 cell line	14.3 and 17.6 μM			(44–48)
			Human breast carcinoma MCF-7 cell line and Du145 prostatic carcinoma cell line	41.74 and 30.56 μmol/L; 89.72 and 61.36 μmol/L
			Human breast adenocarcinoma SK-BR-3 Cell Line	6.6 μM
		Hemsleya penxianensis	Breast carcinoma MCF-7 cell line and Human cervical carcinoma HeLa cell line	2.25 to 49.44 µM
		Hemsleya pengxianensis var. jinfushanensis	Prostate carcinoma Du145 cell line
Cycloartane		Cimicifuga foetida	Human breast carcinoma MDA-MB-231 cell line	6.74 μM and 10.21 μM			(49–51)
			Breast carcinoma MCF-7 cell line	5.86 - 14.21 μm
		Cimicifuga yunnanensis	Human breast cancer cells, MCF-7, MDA-MB-231 and SK-BR3	0.1 – 5.5 µg/ml
Dammarane		Gynostemma pentaphyllum	Breast carcinoma MCF-7 cell line and human breast surface epithelial cells MCF-10a	6.85–52.4 μM			(52–54)
		Panax ginseng	Human breast cancer cell line MCF-7 and prostate carcinoma PC-3 cell line	10–60 μM
		Cleome khorassanica Bunge & Bien	Prostate cancer cell lines DU-145 and LNCaP	11.07–54.82 μM
Euphane		Cassipourea lanceolata Hibiscus tiliaceus Phomopsis chimonanthi	Human ovarian cancer A2780 cell line Human cervical carcinoma HeLa cell line Human breast carcinoma MDA-MB-231 cell line	17 μg/ml 11.5 μmol/L 19.87 μM			(55–57)
Lanostane		Ganoderma luteomarginatum	Human cervical carcinoma HeLa cell line	1.29 μM			(58, 59)
		Ganoderma lucidum	Human breast carcinoma MDA-MB-231 cell line	21.2 - 158.7 μM
Prostane		Alisma plantago-aquatica L. var. orientale Samuelson	Human ovary adenocarcinoma SK-OV3 cell line	7.5 µg/ml			(60)
Tirucallane/Apotirucallane		Scorzonera divaricate	Human cervical carcinoma HeLa cell line	24.5 μM			(55, 61–66)
		Hibiscus tiliaceus	Human cervical carcinoma HeLa cell line	19.9 μmol/L
		Amphipterygium adstringens	Breast carcinoma MCF-7 cell line and prostate carcinoma PC-3 cell line	18.4–31.5 μM and 27.4–32.6 μM
		Luvunga scandens	Breast carcinoma MCF-7 cell line	13.8 μM and 27.5 μM
		Walsura chrysogyne	Breast carcinoma MCF-7 cell line	32.2 μM and 62.5 μM
		Ficus carica	Breast carcinoma MCF-7 cell line	17.94 μM
		Picrasma quassioides	Breast carcinoma MCF-7 cell line	8.5–10 μM
	Pentacyclic triterpenoids
	Baccharene type
Friedelane		Siphonodon celastrineus Griff	Human cervical carcinoma HeLa cell line and human breast carcinoma MDA-MB-231 cell line	Not cytotoxic			(67–70)
		Anchietea pyrifolia	Human cervical carcinoma HeLa cell line	5.7–45.0 μM
		Maytenus robusta	Murine 4T1 breast cancer cell	9.80 µM, 1.23 µM, 98.10 µM, 58.10 µM, 23.10 µM, 11.00 µM
		Garcinia celebica	Human breast cancer MCF-7 cell line	82 and 70 µM
Glutinane		Walsura pinnata	Prostate adenocarcinoma PC-3 cell line Breast adenocarcinoma (MDA-MB-231)	55.3 ± 3.9 µM			(71, 72)
			Breast adenocarcinoma MCF-7 cell line Cervical adenocarcinoma (HeLa S3)	92.9 ± 3.1 µM
			Cervical carcinoma (SiHa)	60.9 ± 2.3 µM
			Prostate carcinoma (DU 145)	59.7 ± 0.9 µM >100b
		Tibouchina urvilleana	Prostate carcinoma PC-3 cell line Breast carcinoma MCF-7 cell line	87.2 ± 2.1 µM
Lupane		Siphonodon celastrineus Griff	Human cervical carcinoma HeLa cell line and human breast carcinoma MDA-MB-231 cell line	Not cytotoxic			(68, 73–75)
		Davidia involucrata	Breast carcinoma MCF-7 cell line	7.26–12.37 μM
		Akebia Trifoliate	Human cervical carcinoma HeLa cell line	81.49 μM
		Potentilla discolor Bunge	Breast carcinoma MCF-7 cell line	30.78 μM
Multiflorane		Trichosanthes kirilowii	Human ovarian carcinoma OVCAR-3 and OVCAR-6 cell line	1.79 and 2.06 μM			(74, 76, 77)
		Akebia trifoliate	Human cervical carcinoma	26.5–51.9 μM
		Turraea spp.	HeLa cell line A2780 human ovarian cancer cell line	20 μM
Oleanane		Siphonodon celastrineus Griff	Human cervical carcinoma HeLa cell line and human breast carcinoma MDA-MB-231 cell line	Not cytotoxic			(68, 72, 78–80)
		Luffa cylindrical	Human breast cancer MDA-MB-231 and MCF-7 cell line	41.72 μM and 48.17 μM
		Stauntonia brachyanthera	Human breast cancer MDA-MB-231cell line	27.73 μM, 97.33 μM and 29.23 μM
		Tibouchina Urvilleana	Breast carcinoma MCF-7 cell line
		Clematis ganpiniana	Invasive ductal carcinoma BT474 and SUM1315 cell lines and human breast adenocarcinoma cell lines MCF-7, MDA-MB-231	5, 10, 20, 40 and 80 mg/ml
Taraxerane		Saussurea graminea	Human cervical carcinoma HeLa cell line and breast carcinoma MCF-7 cell line	9.47 -30.14 μM and 9.27 -30.35 μM			(72, 73, 81)
		Davidia involucrate	Breast carcinoma MCF-7 cell line	41.34 μM and 42.54 μM
		Tibouchina urvilleana	Breast carcinoma MCF-7 cell line
Ursane		Siphonodon celastrineus Grif	Human cervical carcinoma HeLa cell line and human breast carcinoma MDA-MB-231 cell line	Not cytotoxic to any of the cell lines tested			(68, 72, 73, 82)
		Davidia involucrate	Human breast cancer MCF-7 cell line
		Crataegus pinnatifida	Human ovary adenocarcinoma SK-OV3 cell line	36.3–76.4 μM
		Tibouchina urvilleana	Human breast cancer MCF-7 cell line	3.27 μg/ml
	Hopane type
Gammacerane		Abies veitchii A. mariesii	Human endometrial carcinoma RL-95 cell line				(83)
Hopane		Parmotrema sancti-angelii	Human breast cancer MCF-7 cell lin		47.08 ± 2.64 µg/ml		(84–86)
		Cnidoscolus spinosus	Human breast cancer MCF-7 cell line and prostate carcinoma PC-3 cell line		Not cytotoxic
		Megacodon stylophorus	Human cervical carcinoma HeLa cell line and breast cancer MCF-7 cell line		3.6 µM; 7.5 µM
Neohopane		Carissa carandas L.	Human cervical carcinoma HeLa cell line and prostate carcinoma PC-3 cell line			6.87 µM; 12.60 µM	(87)