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MOB, RASSF, SAV scaffolding proteins play an essential role in activating the Hippo pathway. β-PIX and Ajuba scaffolds inhibit LATS's ability to phosphorylate YAP and trigger a positive response to JNK or ERK phosphorylation. ERK can phosphorylate KIBRA (upstream activator of SAV) and increase growth. RAS-MAPK scaffolds enhance MAPK signaling and help to suppress Hippo signaling. Activation of YAP transcription increases IQGAP, EGFR, and growth factors.
