Table 2.
Functions of m6A erasers in cancer.
| m6A Enzyme system | Cancer type | Overexpressed or Underexpressed | Target(s) | Changes in the behavior of tumor cells | Reference |
|---|---|---|---|---|---|
| Erasers | |||||
| FTO | pancreatic carcinoma | Overexpressed | MYC and bHLH | Promote cell proliferation | (93) |
| Non-Small Cell Lung Cancer | Overexpressed | USP7 | Promote cell proliferation | (94) | |
| Cervical squamous carcinoma | Overexpressed | β-catenin and ERCC1 | Regulate the chemo-radiotherapy resistance of cervical squamous cell carcinoma | (95) | |
| Cervical squamous carcinoma | Overexpressed | E2F1 and MYC | Promote proliferation and migration | (96) | |
| Cervical squamous carcinoma | Overexpressed | BNIP3 | In collaboration with YTHDF2 and promote cell proliferation, colony formation and metastasis | (97) | |
| hepatoma | Overexpressed | PMK2 | Regulate the cell cycle and ectopic expression is associated with poor prognosis | (98) | |
| acute myelogenous leukemia | Overexpressed | ASB2 and RARA | Promote survival, proliferation, and cloning | (99) | |
| ALKBH5 | glioblastoma | Overexpressed | FOXM1 | Promote cell self-renewal and its occurrence in brain tumor | (100) |
| breast carcinoma | Overexpressed | NANOG | Maintain the tumor microenvironment | (101) | |
| Epithelial ovarian carcinoma | Overexpressed | EGFR-PIK3CA-AKT-mTOR signaling pathway and BCL-2 | Enhance the autophagy in SKOV3 cells | (102) | |
| gastric carcinoma | Overexpressed | NEA-T1 and E2H2 | Promote the invasion and metastasis | (103) | |
| lung adenocarcinoma | Overexpressed | FOXM1 | Promote tumor progression | (104) | |
| pancreatic cancer | Underexpressed | WIF-1 | Inhibit tumorigenesis and make tumor cells more sensitive to chemotherapy | (105) | |
| pancreatic cancer | Underexpressed | ATM-CHk2-p53/CDC25C | Inhibit the growth of tumor cells | (106) |