Table 3.
Functions of m6A readers in cancer.
| m6A Enzyme system | Cancer type | Overexpressed or Underexpressed | Target(s) | Changes in the behavior of tumor cells | Reference |
|---|---|---|---|---|---|
| Readers | |||||
| YTHDF1 | Non-Small Cell Lung Cancer | Overexpressed | CDK2, CDK4 and Cyclin D1 | Inhibit cell proliferation and the formation of a xenograft tumor | (109) |
| colorectal cancer | Overexpressed | Wnt/β-catenin | Inhibiting the tumorigenicity | (110) | |
| ovarian carcinoma | Overexpressed | EIF3C | Promote the occurrence and metastasis | (58) | |
| YTHDF2 | pancreatic carcinoma | Overexpressed | YAP signal transduction | Inhibition of epithelial mesenchymal transformation | (111) |
| lung cancer | Overexpressed | Glucose-6-phosphate dehydrogenase | Promote cell proliferation | (112) | |
| hepatocellular carcinoma | Underexpressed | EGFR 3′-UTR | Inhibit the proliferation and growth | (116) | |
| hepatocellular carcinoma | Overexpressed | OCT4 5′-UTR | Promote CSC liver phenotype and tumor metastasis | (115) | |
| YTHDF3 | germinal cell tumor of testis | Overexpressed | Oncogene | (117) | |
| YTHDC2 | Colorectal carcinoma | Overexpressed | HIF-1α | Promote the metastasis | (118) |
| IGF2BP1 | Hepatocellular Carcinoma | Overexpressed | C-MYC and MKI67 | Regulate cell proliferation and apoptosis | (119) |