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. 2021 Jan 21;11:634634. doi: 10.3389/fgene.2020.634634

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Copyright © 2021 Ren, Yang, Li, Xie, Hu, Qin and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Construction of risk assessment signature. (A) 241 promising candidates (P ≤ 0.05), including 32 protective and 209 risk markers. (B) The optimal λ value of 0.02774519 was selected to identify the most robust markers for prognosis in LASSO regression. (C) A combination of 21 genes remained with their individual non-zero LASSO coefficients. (D) The distribution of LASSO coefficients of the gene signature. The blue bars represent protective biomarkers and the red bars represent risk biomarkers.