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. 2021 Jan 21;11:634634. doi: 10.3389/fgene.2020.634634

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Copyright © 2021 Ren, Yang, Li, Xie, Hu, Qin and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Survival analysis of four immune-related biomarkers. (A) Interaction network of TYMS, E2F7, SPDL1, and TK1. TYMS is the target of the FDA-approved drug Pemetrexed. (B) Heatmap of CD8 T cell-related genes. (C) Kaplan–Meier survival curve. It showed the significant survival difference between patients with low expression of TYMS, E2F7, SPDL1, TK1 (group 1), and other patients (group 2). (D) Kaplan–Meier survival curve. Group 2 was further classified into group 3 and group 4 according to our defined risk score index. It displayed the significant survival difference among the three groups, including the low proliferation group (group 1), the high proliferation and low risk score group (group 3), and the high proliferation and high risk score group (group 4).