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. 2021 Jan 21;9:626027. doi: 10.3389/fcell.2021.626027

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Copyright © 2021 Lv, Liu, Zhang, Hu, Wu and Ren.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The schematic diagram illustrates the role of circCOL5A1 as a ceRNA for miR-7-5p to release Epac1 in regulating the pathological phenotype of keloids. circCOL5A1 was generated by the head-to-tail splicing of COL5A1 in the nucleus and then functioned as ceRNA in the cytoplasm. circCOL5A1 reversed miR-7-5p-induced enhancement of HKFs biological function via the PI3K/Akt signaling pathway, including proliferation, migration, apoptosis, collagen production, and myofibroblast activation. Mechanismly, circRNAs could restore the expression of miR-7-5p target Epac1, forming the circCOL5A1/miR-7-5p/Epac1 regulating axis. The miR^∗ represented a segment of RNA on the pre-miRNA, and its position happened to be opposite that of the mature miRNA.